Is nelfinavir exposure associated with cancer incidence in HIV-positive individuals?

Is nelfinavir exposure associated with cancer incidence in HIV-positive individuals?

OBJECTIVE Nelfinavir exhibits potent anticancer properties against a range of tumours. However, in 2006/2007, nelfinavir supplies were accidently contaminated with a carcinogen. This analysis investigated the association between nelfinavir use and cancer risk in HIV-positive persons. DESIGN Observational cohort study. METHODS D:A:D study data was analysed using Poisson regression models to ...

associated factors of suicidal thoughts in hiv-positive individuals

objective: as a first study, suicidal ideation and its correlates have been evaluated in iranian hiv positive population . methods: one hundred and fifty hiv-positive individuals were recruited in this cross-sectional study. the hospital anxiety and depression scale (hads), positive and negative suicide ideation (pansi), pittsburgh sleep quality inventory (psqi) and somatization subscale of sym...

Associated Factors of Suicidal Thoughts in HIV-Positive Individuals.

OBJECTIVE As a first study, suicidal ideation and its correlates have been evaluated in Iranian HIV positive population. METHODS One hundred and fifty HIV-positive individuals were recruited in this cross-sectional study. The Hospital Anxiety and Depression Scale (HADS), Positive and Negative Suicide Ideation (PANSI), Pittsburgh Sleep Quality Inventory (PSQI) and Somatization subscale of Symp...

Serum Level of Soluble CD226 Receptor in Healthy Individuals is Highly Variable and Associated with Age

Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir.

BACKGROUND Human epidermal growth factor receptor 2 (HER2)-positive breast cancer is highly aggressive and has higher risk of recurrence than HER2-negative cancer. With few treatment options available, new drug targets specific for HER2-positive breast cancer are needed. METHODS We conducted a pharmacological profiling of seven genotypically distinct breast cancer cell lines using a subset of...